The Regional Medical Center (RMC) is a regional healthcare system with a 286-bed acute care hospital and 23 primary care and specialty care practices. The hospital, located in Orangeburg, also maintains a primary care facility in Holly Hill. Additionally, HEALTHPLEX, one of RMC's services, offers a full range of gym services featuring a variety of cardio equipment and weight training at its Holly Hill location.
Holly Hill is also served by Family Health Center and a number of private physicians and family practitioners.
Other area hospitals include Berkeley County Hospital, Summerville Medical Center, and Trident Medical Center.